ABSTRACT
The emergence of coronavirus disease 2019 (COVID-19) as a pandemic threatens the entire world resulting in severe consequences for people's health. Pregnant patients with COVID-19 had immune dysregulation that could result in abnormal pregnancy outcomes such as hydatidiform mole (HM), recurrent pregnancy loss, and early-onset preeclampsia. In this article, we tried to summarize the possible association between COVID-19 and the HM's development by reviewing the role of NOD-Like Receptor (NLR) Family Pyrin Domain Containing 7 (NLRP7), cytokines, zinc, and leukocytes in the pathogenesis of HM.
Subject(s)
COVID-19/immunology , Hydatidiform Mole/immunology , Leukocytes/immunology , Pregnancy Complications, Infectious/immunology , SARS-CoV-2/physiology , Adaptor Proteins, Signal Transducing/metabolism , Cytokines/metabolism , Female , Humans , Pandemics , Pregnancy , Pregnancy OutcomeABSTRACT
The pandemic of coronavirus disease-2019 (COVID-19) could harm the reproductive and sexual health of both males and females. This could be through psychological, immunological, or systemic effects. In this article, we tried to elucidate the mechanisms that could explain the current and future genital affection of COVID-19 patients.